University Hospital Son Espases
Our research lines are focused in investigating (i) the mechanisms of resistance and epidemiology of multidrug resistant (MDR) pathogens (ii) implementation of programs of antimicrobial stewardship (iii) the regulatory networks of resistance mechanisms (iv) bacterial adaptive strategies, including hypermutation and biofilms (v) in vitro and in vivo models to evaluate antimicrobial activity and resistance dynamics (vi) interplay between antimicrobial resistance and virulence and (vii) host-pathogen interactions. Although also interested in MDR Enterobacteriaceae and MRSA, our research is particularly focused in Pseudomonas aeruginosa infections. Some of our most relevant contributions include (i) elucidating the role of hypermutable P. aeruginosa in antibiotic resistance and persistence of chronic respiratory infections (Oliver A. Science. 2000; 288:1251; Pal C. Nature. 2007; 450:1079), (ii) characterizing several relevant components of P. aeruginosa β-lactam resistance pathways (Juan C. AAC. 2006; 50:1780; Moyá B. PLoS Pathog. 2009; 5:e1000353) (iii) describing the molecular epidemiology, resistance mechanisms and impact of MDR/XDR P. aeruginosa infections (Gutiérrez O. AAC. 2007; 51:4329; Cabot G. AAC. 2011; 55:1909; Cabot G. AAC. 2012; 56:6349), (iv) evaluation of the new antipseudomonal agent ceftolozane (Juan C. AAC. 2010; 54:846; Moyá B. ACC. 2010; 54:1213; Moyá B. AAC. 2010; 54:3933; Moyá B. AAC. 2012; 56:477) and (iv) deciphering relevant aspects of host-pathogen interactions in P. aeruginosa infections (Barbier M. JID. 2008; 197:465; Barbier M. Mbio. 2013; e00207).
Dr. José Luis Pérez