University Hopsital Ramón y Cajal
Our group is a multi-disciplinary team which integrated clinical and basic microbiologists and infectious diseases practitioners belonging to Hospital Ramón y Cajal-Instituto de Ramón y Cajal de Investigación Sanitaria (IRYCIS), Schooll of Pharmacy-Universidad Complutense and Centro Nacional de Biotecnología-Consejo Superior de Investigaciones científicas. Our research lines are mainly focused in the field of i) antimicrobial resistance mechanisms including epidemiology of emergence and dynamics of spread of multidrug (MDR) resistance bacteria, interplay of resistance mechanisms, horizontal gene transfer elements and clonal dispersion and the role of resistome in the dispersion of antimicrobial resistance, ii) predicting models for the emergence and evolution of antibiotic resistance mechanisms and functional roles of antibiotic resistance; iii) host interaction of yeast and proteomics, iv) bacterial chronic infection models, including osteoarticular infections and bronchopulmonary pathogenic colonization in cystic fibrosis, bronchiectasis and chronic obstructive pulmonary disease; v) antibiotic use and resistance; vi) management and infectious diseases in transplant patients with special focus on fungal and viral infections, including interplay of HIV and HVC, and vii) influence of the intestinal microbiome on disease. Main contributions, among others have been the description of new resistance mechanism in Enterobacteriaceae, including extended-spectrum β-lactamases and carbapenemases, description of clinical outcomes and epidemiological features in patients with prosthetic joint infections, role of resistome on the expression and dispersion of antimicrobial resistance, proteomics of yeast and guidelines on the management of fungal and viral infections in transplant patients. Overall, the group has nearly 200 publications in the last five years. Their research projects are founded by EU, Spanish research agencies, scientific societies and pharmaceutical industry.
Dr. Rafael Cantón