Santa Creu i Sant Pau Hospital

The Center for Research in Infectious Pathology and Clinical Microbiology (CREPIMC) forms part of the Institute of Biomedical Research (IIB Sant Pau), a research centre recognized by the Health Department in Spain. IIB Sant Pau is made up of various entities that perform high-quality research in the fields of basic and clinical medicine, epidemiology, and health services.
CREPIMC is a multi-disciplinary group of researchers from the Department of Microbiology (a recognized Group of Excellence by the Generalitat de Catalunya; 2009SGR01394), the Infectious Diseases Unit at Hospital Santa Creu i Sant Pau, and the Renal Transplant Unit at the Puigvert Foundation in Barcelona.

Our research lines focus on three main interrelated areas. The first of these is antimicrobial resistance. This area includes the study of molecular epidemiology (population and clonality studies in bacteria, mycobacteria, fungi and viruses), molecular bases of bacterial resistance to antibiotics, vectors that convey resistance genes (plasmids, transposons, integrons, phages), and the use of molecular techniques in diagnosis of infectious diseases. The second area is infectious disease, and emphasizes research related to bacteraemia and endocarditis, nosocomial infections, prosthetic joint infections, central nervous system infections, and tuberculosis. The third area is related to studies in urology, nephrology and andrology. Here the focus is on infections – especially cytomegalovirus – in connection with renal transplants.

Our most relevant, recent contributions include: epidemiological descriptions of new resistance mechanisms in Enterobacteriaceae, including extended-spectrum β-lactamases, class C β-lactamases, carbapenemases, and aminoglycosides resistance genes; epidemiological studies of these resistance mechanisms in various ecosystems (human, water, animals and food); descriptions of the genetic basis of dispersion of the above-mentioned resistance mechanisms; implications of bacteriophages on diffusion of resistance among bacteria; reports on clinical outcomes and epidemiological features in patients with prosthetic joint infections; and the publication of guidelines for the management of fungal and viral infections in transplant patients.

Our group has also been involved in the molecular typing of microorganisms, both tracking epidemics to study the phylogeny of populations of Neisseria meningitidis and studying the influence of immigrants on the epidemiology of tuberculosis in the city of Barcelona.

Over the last five years, the group has generated over 100 publications in international journals. Our research projects are funded by EU and Spanish research agencies, scientific societies and the pharmaceutical industry.

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Group Coordinator

Dr. Pere Coll