Mechanisms leading to in vivo ceftolozane/tazobactam resistance development in Pseudomonas aeruginosa 

REIPI researchers, led by H. Son Espases Group, Have characterized the mechanisms driving resistance development to the new antipseudomonal combination ceftolozane/tazobactam in 5 patients treated for MDR Pseudomonas aeruginosa infections. In all five cases, the same clone was detected for the susceptible/resistant pairs; the widespread ST175 high-risk clone in four of the cases and ST179 in the…

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The use of a single antibiotic may be enough to treat mild infections caused by resistant bacteria. Researchers from the Spanish Network of Research in Infectious Diseases (REIPI) have demonstrated it.

The investigations have been developed in infections caused by a bacterium called Klebsiella pneumoniae, which can be multiresistant. Until now, it was recommended to treat these infections with a combination of antibiotics. The research has been carried out in the Spanish Network of Research in Infectious Diseases (REIPI) and has been coordinated by researchers from…

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The urinary tract conditions of patients with Escherichia coli infection improve fosfomycin activity.

The steps by which E. coli strains harboring mutations related to fosfomycin resistance arise and spread during urinary tract infections (UTIs) are far from being understood. A study performed by several REIPI groups (Hospital Universitario Virgen del Rocío, Hospital Universitario Virgen Macarena and Centro Nacional de Biotecnología) evaluates the effects of the urinary tract conditions…

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First insights into the role of vrf, a newly characterized gene of Salmonella Typhimurium

Salmonella Typhimurium is an important pathogen responsible for causing food-borne disease. This bacterium carries conserved virulence factors involved in the process of infection, allowing survival, replication and invasion inside the host cell in order to cause the disease. In this study, researchers from Dr. Jordi Vila’s group at the Barcelona Institute for Global Health (ISGlobal)-…

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Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial. Lancet Haematol 2017

The optimal duration of empirical antibacterial therapy for febrile neutropenia without microbiological diagnosis in haematological patients is not well defined; the classical approach of continuing antimicrobial therapy until neutrophil recovery may prolong it unnecessarily. This study aimed to establish whether the discontinuation of antimicrobial therapy driven by a clinical approach regardless of neutrophil recovery would…

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The prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients

This study is the first assessment of longitudinal persistence of Escherichia coli ST131, including both ESBL and non-ESBL-producing isolates. This clone is considered the most important in the increased prevalence of quinolones resistant isolates and one of those responsible for the worldwide dissemination of the blaCTX-M-15 gene. Our results showed a rapid dynamic of ST131…

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Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial

How Long? the just Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy innecessarily. We did an investigator-driven, superiority, open-label, randomised, controlled phase 4 clinical trial in six hospitals in Spain. For the experimental group, EAT was withdrawn after 72 h or more…

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Genomics of Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa

REIPI researchers coordinated by the Hospital Son Espases Group have analyzed the molecular epidemiology and the whole genome sequencing resistome of a large collection of XDR P. aeruginosa strains isolated from Spanish hospitals. The main conclusions of the study are as follows: (1) Most strains were resistant to all antipseudomonal agents except colistin, amikacin and…

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