Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy.

“The sharp increase in cases of MDR Acinetobacter baumannii infections in recent years prompted by WHO to list this pathogen as a critical pathogen. The development of new approaches that adjuvant the scarcity of clinically relevant antibiotics for treatment of infections by MDR A. baumannii is an urgent need. Researchers from the University Hospital Virgen…

Details

Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli.

Journal of Antimicrobial Chemotherapy 2018 (In press)   This study was coordinated at University Hospital Virgen Macarena in collaboration with the Centro Nacional de Biotecnología. This work shows that suppression of the SOS response (through recA deleted) blocks the evolution towards clinical quinolone resistance across a range of E. coli phenotypes from highly susceptible to…

Details

Prospective Surveillance Triazole Resistance fungal in Spain (FILPOP2 study)

Antifungal resistance is increasing by the emergence of intrinsically resistant species and by the development of secondary resistance in susceptible species. A previous study performed in Spain revealed levels of azole resistance in molds between 10 to 12.7% but secondary resistance in A. fumigatus was not detected. We used itraconazole supplemented media to select resistant…

Details

Analysis of intestinal colonization by ESBL-E. coli reveals the emergence in Europe of CTX-M-27 associated with clade C1-M27 of ST131 clone

– This finding represents an epidemiological change in extended-expectrum-beta-lactamases (ESBLs) distribution in Europe – This study results from the collaboration of the Preventive Medicine and Microbiology Departments at Hospital Universitario Ramón y Cajal (Madrid) with a European multicentre project (R-GNOSIS) funded by the EU and it has been recently awarded as best communication in the…

Details

I Jornada sobre Bilógicos, Seguridad e Infección (BI-SEIF). Madrid, 19 de Septiembre de 2018

CARTA DE BIENVENIDA   Nos complace presentar las Primeras Jornadas sobre Biológicos Seguridad e Infección (BI-SEIF). Estas Jornadas nacen con el propósito de desarrollar las bases para el uso seguro de los nuevos fármacos biológicos dirigidos al tratamiento de cada vez más enfermedades en el campo de la Oncología, Hematología, Reumatología, Dermatología, Aparato Digestivo, Nefrología,…

Details

Colonization with Enterobacteriaceae-Producing ESBLs, AmpCs, and OXA-48 in Wild Avian Species, Spain 2015-2016

Summary. Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried…

Details

Candida periprosthetic joint infection: a rare and difficult-to-treat infection

Candida periprosthetic joint infection (CPJI) poses a challenge, as it is a rare infection and there are no clear guidelines regarding the best management strategies. Candida spp. often grow as a biofilm which may contribute to persistence and relapse of the infection. Azoles have been the main used agents with high failure rates, likely because…

Details

«Bacteriophages, Toxin-Antitoxin systems: Targets to develop of new treatments against bacterial persister cells»

«Bacteriophages, Toxin-Antitoxin systems: Targets for developing new treatments against bacterial persister cells» Researchers from the Spanish Network of Research in Infectious Diseases (REIPI) from 6 hospitals: A Coruña Hospital-INIBIC (A Coruña), Macarena Hospital-IBIS (Sevilla), Virgen del Rocio Hospital-IBIS (Sevilla), Clinic Hospital-IS Global (Barcelona), Marques de Valdecilla-IFIMAV (Santander) and Reina Sofia Hospital-IMIBIC (Cordoba) worked in the…

Details

Prof. Jesús Rodríguez-Baño, coordinator of the Spanish network for research in infectious diseases (REIPI), is the new president of the Executive Committee of The European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

ESCMID is self-defined as a non-profit organization whose mission is to improve the diagnosis, treatment and prevention of infection-related diseases. This is achieved by promoting and supporting research, education, training, and good medical practice. Prof. Rodríguez-Baño, MD PhD, is specialist in Infectious Diseases at the Department of Infectious Diseases and Clinical Microbiology, Hospital Virgen Macarena,…

Details

Mechanisms leading to in vivo ceftolozane/tazobactam resistance development in Pseudomonas aeruginosa

REIPI researchers, led by H. Son Espases Group, Have characterized the mechanisms driving resistance development to the new antipseudomonal combination ceftolozane/tazobactam in 5 patients treated for MDR Pseudomonas aeruginosa infections. In all five cases, the same clone was detected for the susceptible/resistant pairs; the widespread ST175 high-risk clone in four of the cases and ST179 in the…

Details

The use of a single antibiotic may be enough to treat mild infections caused by resistant bacteria. Researchers from the Spanish Network of Research in Infectious Diseases (REIPI) have demonstrated it.

The investigations have been developed in infections caused by a bacterium called Klebsiella pneumoniae, which can be multiresistant. Until now, it was recommended to treat these infections with a combination of antibiotics. The research has been carried out in the Spanish Network of Research in Infectious Diseases (REIPI) and has been coordinated by researchers from…

Details