National Center for Microbiology (Mycology)
The Mycology department of the National Centre for Microbiology has a broad experience based on almost two decades devoted to the study and research of human fungal infections. The main areas of research are: (i) Standardization of susceptibility testing methods, (ii) development of animal models for fungal infection (iii) detection of resistance mechanisms and (iv) development of diagnostic and identification tools for invasive fungal infections (IFI). In the last years the group has coordinated several studies on epidemiology, antifungal resistance and diagnosis of fungal infections. Two population based surveys of yeast and filamentous fungi and antifungal resistance in Spain have been conducted and are going to be published in the coming months. A clinical trial on the early detection of Invasive Aspergilosis in oncohematological patients by Real Time PCR has also been coordinated by the group and the results are being analyzed nowadays. All these studies have been conducted within the REIPI and in collaboration with several members of the group. In the coming years the main objective of our research group would focus of reducing the incidence and mortality rate of Invasive fungal infections (IFI) following two strategies: (i) Development and implantation of early diagnosis techniques of IFI in Hospitals from the National Health system, and (ii) Analysis of host susceptibility to invasive disease due to Aspergillus and determination of the transcriptome profile of these patients.
Dr. Manuel Cuenca Estrella