Infectious Diseases Research Group of Hospital Vall d’Hebron published a study in American Journal of Transplantation with the purpose of characterizing the epidemiology of respiratory virus (RV) and the relationship between RVs and its immunomodulatory effects (acute rejection, opportunistic infections) in lung transplant recipients.
It was evaluated a prospective cohort study (2009-2014) performing a systematic collection of nasopharyngeal swabs in asymptomatic patients in seasonal changes, respiratory tract infections and AR. Samples screened with multiplex RT-PCR.
A total of 1094 smears were collected in 98 patients documenting a high incidence of RVI with an overall prevalence of 2.33 infections per patient-year. About half of upper respiratory Infections (48.5%) and tracheobronchitis (22/56, 39.3%) were caused by picornavirus, whereas paramyxovirus (4/9, 44.4%) and influenza (2/9, 22.2%) were main causative RV of pneumonia. RV infections are associated with immediate allograft dysfunction as assessed by spirometry outcome. Acute Rejection, P.aeruginosa colonization/infection and CMV infection was associated with the presence of RV in the previous three months.
The study emphasizes the need for monitoring of respiratory virus infections in this high-risk population and the need for prevention through vaccination (flu) and to avoid, insofar as possible, the contact time of maximum risk.
Peghin M, Hirsch HH, Len Ó, Codina G, Berastegui C, Sáez B, Solé J, Cabral E, Solé A, Zurbano F, López-Medrano F, Román A & Gavaldá J. Epidemiology and Immediate Indirect Effects of Respiratory Viruses in Lung Transplant Recipients: A 5-Year Prospective Study. Am J Transplant; doi: 10.1111/ajt.14042.