Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy.

“The sharp increase in cases of MDR Acinetobacter baumannii infections in recent years prompted by WHO to list this pathogen as a critical pathogen. The development of new approaches that adjuvant the scarcity of clinically relevant antibiotics for treatment of infections by MDR A. baumannii is an urgent need. Researchers from the University Hospital Virgen…

Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli.

Journal of Antimicrobial Chemotherapy 2018 (In press)   This study was coordinated at University Hospital Virgen Macarena in collaboration with the Centro Nacional de Biotecnología. This work shows that suppression of the SOS response (through recA deleted) blocks the evolution towards clinical quinolone resistance across a range of E. coli phenotypes from highly susceptible to…

«Bacteriophages, Toxin-Antitoxin systems: Targets to develop of new treatments against bacterial persister cells»

«Bacteriophages, Toxin-Antitoxin systems: Targets for developing new treatments against bacterial persister cells» Researchers from the Spanish Network of Research in Infectious Diseases (REIPI) from 6 hospitals: A Coruña Hospital-INIBIC (A Coruña), Macarena Hospital-IBIS (Sevilla), Virgen del Rocio Hospital-IBIS (Sevilla), Clinic Hospital-IS Global (Barcelona), Marques de Valdecilla-IFIMAV (Santander) and Reina Sofia Hospital-IMIBIC (Cordoba) worked in the…

Prof. Jesús Rodríguez-Baño, coordinator of the Spanish network for research in infectious diseases (REIPI), is the new president of the Executive Committee of The European Society of Clinical Microbiology and Infectious Diseases (ESCMID).

ESCMID is self-defined as a non-profit organization whose mission is to improve the diagnosis, treatment and prevention of infection-related diseases. This is achieved by promoting and supporting research, education, training, and good medical practice. Prof. Rodríguez-Baño, MD PhD, is specialist in Infectious Diseases at the Department of Infectious Diseases and Clinical Microbiology, Hospital Virgen Macarena,…

The use of a single antibiotic may be enough to treat mild infections caused by resistant bacteria. Researchers from the Spanish Network of Research in Infectious Diseases (REIPI) have demonstrated it.

The investigations have been developed in infections caused by a bacterium called Klebsiella pneumoniae, which can be multiresistant. Until now, it was recommended to treat these infections with a combination of antibiotics. The research has been carried out in the Spanish Network of Research in Infectious Diseases (REIPI) and has been coordinated by researchers from…

Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial. Lancet Haematol 2017

The optimal duration of empirical antibacterial therapy for febrile neutropenia without microbiological diagnosis in haematological patients is not well defined; the classical approach of continuing antimicrobial therapy until neutrophil recovery may prolong it unnecessarily. This study aimed to establish whether the discontinuation of antimicrobial therapy driven by a clinical approach regardless of neutrophil recovery would…