Impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain, 2013. (Estudio coordinado por REIPI, GIH y GEMARA)

83 hospitals (about 40,000 hospital beds) prospectively collected nonduplicate Enterobacteriaceae using the screening cutoff recommended by EUCAST. A total of 702 Enterobacteriaceae isolates met the inclusion criteria; 379 (54%) were CPE. OXA-48 (71.5%) and VIM-1 (25.3%) were the most frequent carbapenemases, and K. pneumoniae (74.4%), Enterobacter cloacae (10.3%), and E. coli (8.4%) were the species…

High recombinant frequency in extra-intestinal pathogenic Escherichia coli strains

Recombination of DNA sequences is a fundamental evolutive mechanism that promotes genetic diversity, facilitating the integration of foreign DNA and the rearrangement of intra-chromosomal genes. It has been hypothesized that natural selection should favor high recombination rates among pathogens, as they face additional selection pressures from host defenses. In an article recently appeared, an international…

Lack of association between genotypes and haematogenous seeding infections in a large cohort of patients with methicillin-resistant Staphylococcus aureus bacteraemia from 21 Spanish hospitals.

Dear collegues, Information on the association between methicillin-resistant Staphylococcus aureus (MRSA) genotypes and clinical outcome is scarce. We sought to determine the relationship between certain MRSA genotypes and poor clinical outcomes. To assess this issue, we performed a multicentre cohort study, leaded by Hospital Universitari de Bellvitge, and conducted in 21 hospitals in Spain. The…

The group of Microbiology of the Hospital Universitario La Coruña and D-glutamate

The group of Microbiology of the Hospital Universitario La Coruña, Spain, led by Dr. Germán Bou has recently performed an invention related to a technique of production of live attenuated bacterial vaccines auxotrophic for D-glutamate (D-Glu) using as application model the nosocomial pathogens Pseudomonas aeruginosa and Acinetobacter baumannii . It has just been patented in…

Evaluation of a Loop-Mediated Isothermal Amplification-Based Methodology To Detect Carbapenemase Carriage in Gram-Negative Bacterial Clinical Isolates

The emergence and dissemination of different Gram-negative bacterial species producing acquired beta-lactamases able to hydrolyze carbapenems (carbapenemases) currently represent a major public health threat. The implementation of containment measures to prevent their further spread mostly relies on the rapid detection of isolates carrying such enzymes. At the department of clinical microbiology of the Hospital Clínic…

ESCMID Postgraduate Technical Workshop Improving Patient Safety: the Neglected Impact of Age and Gender

Estimados Investigadores,

a continuación les facilitamos el programa del curso  ESCMID Postgraduate Technical Workshop Improving Patient Safety: the Neglected Impact of Age and Gender.

La Red concederá cuatro becas para poder asistir a dicho curso.

Aquellos investigadores que estén interesados, por favor, remitan sus solicitudes a la Secretaría Técnica de la Red.

Descargue el programa aquí

The Type III Secretion System (TTSS) genotype, associated with defined resistance profiles, plays a major role in the mortality of P. aeruginosa bloodstream infections.

REIPI researchers leaded by Carmen Peña (H. Bellvitge) and Antonio Oliver (H. Son Espases) performed a post hoc analysis of a published prospective multicenter (10 hospitals) cohort of P. aeruginosa bloodstream infections to evaluate the impact in mortality of TTSS genotypes (exoS, exoT, exoU, and exoY genes) and resistance profiles. Among 590 patients, the 30-day…

N-acetylcysteine selectively antagonizes the activity of imipenem in Pseudomonas aeruginosa by an OprD-mediated mechanism

In a work recently published, a consortium of three REIPI groups (Instituto de Biomedicina de Sevilla-IBIS, Hospital Universitario Son Espases-Palma de Mallorca and Complejo Hospitalario Universitario A Coruña), led by Dr. Jesús Blázquez (IBIS), demonstrated that, in contrast to previous reports, only the activity of imipenem, but not other antibiotics, is clearly affected by N-acetylcysteine…