Analysis of intestinal colonization by ESBL-E. coli reveals the emergence in Europe of CTX-M-27 associated with clade C1-M27 of ST131 clone

– This finding represents an epidemiological change in extended-expectrum-beta-lactamases (ESBLs) distribution in Europe – This study results from the collaboration of the Preventive Medicine and Microbiology Departments at Hospital Universitario Ramón y Cajal (Madrid) with a European multicentre project (R-GNOSIS) funded by the EU and it has been recently awarded as best communication in the…

I Jornada sobre Bilógicos, Seguridad e Infección (BI-SEIF). Madrid, 19 de Septiembre de 2018

CARTA DE BIENVENIDA   Nos complace presentar las Primeras Jornadas sobre Biológicos Seguridad e Infección (BI-SEIF). Estas Jornadas nacen con el propósito de desarrollar las bases para el uso seguro de los nuevos fármacos biológicos dirigidos al tratamiento de cada vez más enfermedades en el campo de la Oncología, Hematología, Reumatología, Dermatología, Aparato Digestivo, Nefrología,…

Colonization with Enterobacteriaceae-Producing ESBLs, AmpCs, and OXA-48 in Wild Avian Species, Spain 2015-2016

Summary. Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried…

Mechanisms leading to in vivo ceftolozane/tazobactam resistance development in Pseudomonas aeruginosa

REIPI researchers, led by H. Son Espases Group, Have characterized the mechanisms driving resistance development to the new antipseudomonal combination ceftolozane/tazobactam in 5 patients treated for MDR Pseudomonas aeruginosa infections. In all five cases, the same clone was detected for the susceptible/resistant pairs; the widespread ST175 high-risk clone in four of the cases and ST179 in the…

The urinary tract conditions of patients with Escherichia coli infection improve fosfomycin activity.

The steps by which E. coli strains harboring mutations related to fosfomycin resistance arise and spread during urinary tract infections (UTIs) are far from being understood. A study performed by several REIPI groups (Hospital Universitario Virgen del Rocío, Hospital Universitario Virgen Macarena and Centro Nacional de Biotecnología) evaluates the effects of the urinary tract conditions…

First insights into the role of vrf, a newly characterized gene of Salmonella Typhimurium

Salmonella Typhimurium is an important pathogen responsible for causing food-borne disease. This bacterium carries conserved virulence factors involved in the process of infection, allowing survival, replication and invasion inside the host cell in order to cause the disease. In this study, researchers from Dr. Jordi Vila’s group at the Barcelona Institute for Global Health (ISGlobal)-…

The prevalence and transmission dynamics of Escherichia coli ST131 among contacts of infected community and hospitalized patients

This study is the first assessment of longitudinal persistence of Escherichia coli ST131, including both ESBL and non-ESBL-producing isolates. This clone is considered the most important in the increased prevalence of quinolones resistant isolates and one of those responsible for the worldwide dissemination of the blaCTX-M-15 gene. Our results showed a rapid dynamic of ST131…