Late onset aspergillosis among kidney transplant recipients -Estudio colaborativo sobre aspergilosis pulmonar invasiva en portadores de trasplante renal –

A multinational retrospective case-control study was developed to asses risk factors of invasive pulmonary aspergillosis among kidney transplant recipients (Clinical Microbiology and Infection 2017 [advanced publication online]). Controls were matched (1:1 ratio) by center and date of transplantation. Sixty-one patients (and their corresponding controls) of 29 hospitals from 10 countries of Europe and the Americas…

Human neutrophils kill Acinetobacter

Using different advanced microscopy techniques, a group of researchers from the REIPI network demonstrated that human neutrophils easily phagocytose and kill Acinetobacter baumannii and A. pittii. After bacteria-cell contact, neutrophils rapidly and continuously engulf and kill bacteria during at least 4 hours of infection in vitro. Also, neutrophils release neutrophil extracellular traps (NETs) against Acinetobacter.…

Blocking cell-wall recycling to potentiate the activity of β-lactams and fosfomycin against Pseudomonas aeruginosa

REPI researchers from H. Son Espases and CNB-CSIC, in collaboration with Canadian and Australian researchers, have evaluated the interconnection between peptidoglycan (PG) recycling, fosfomycin susceptibility and synergy between fosfomycin and β-lactams in Pseudomonas aeruginosa. Mutants defective in AmpG, NagZ or all three AmpD amidases showed a marked increase in fosfomycin susceptibility. Moreover, fosfomycin MICs were…

Live bacteria auxotrophic for D-glutamate as new universal vaccines

Abstract: An innovative strategy to generate bacterial vaccines as alternatives to antibiotics for the prevention of nosocomial infections caused by resistant and/or multiresistant pathogens has been recently published in Nature Communications by REIPI researchers, belonging to the Microbiology Group of the University Hospital and the Biomedical Research Institute of A Coruña. This technology, based on…

Tratamiento combinado VS monoterapia en las bacteriemias por enterobacterias productoras de carbapenemasas. Resultados del proyecto INCREMENT

An article about the combination therapy in bloodstream infections due to carbapenemase-producing Enterobacteriaceae (CPE) has recently been published in The Lancet Infectious Diseases. The results of this study are based on the cohort of the INCREMENT project, an international study coordinated by Hospital Universitario Virgen Macarena and with participation of 13 REIPI centres, as well…

β-lactams /β-lactamase inhibitors might be carbapenem-sparing alternatives for the treatment of bacteremia due to ESBL-producing Enterobacteriaceae in neutropenic patients

BLBLIs might be carbapenem-sparing alternatives for the treatment of BSI due to ESBLs in neutropenic patients https://t.co/4G87Kw3Mz1 — Jordi Carratalà (@jordi_carratala) June 5, 2017 Several researchers at REIPI have participated in this retrospective multicenter international study carried out at 22 centers from nine countries, which has been led by Dr. Carlota Gudiol, and published in…

Two Doses of Influenza Vaccine Improve Immune Response After Solid Organ Transplant

Last May 25th, the New England Journal of Medicine Watch commented the REIPI´s Clinical Trial “Two doses of inactivated influenza vaccine improve immune response in solid organ transplant recipients. Results of TRANSGRIPE1-2, a randomised, controlled clinical Trial“ recently published in the Clinical Infectious Diseases1,2. Vaccination against influenza in solid organ transplant (SOT) recipients may reduce…

Epidemiology and immediate indirect effects of respiratory viruses in lung transplant recipients

Infectious Diseases Research Group of Hospital Vall d’Hebron published a study in American Journal of Transplantation with the purpose of characterizing the epidemiology of respiratory virus (RV) and the relationship between RVs and its immunomodulatory effects (acute rejection, opportunistic infections) in lung transplant recipients. It was evaluated a prospective cohort study (2009-2014) performing a systematic…

Deciphering the resistome of the widespread P. aeruginosa ST175 international high-risk clone through whole genome sequencing

REPI researchers, lead by Hospital Son Espases Group, have used whole genome sequencing (WGS) for the characterization of the frequently extensively-drug resistant (XDR), P. aeruginosa high-risk clone ST175, widely disseminated in Spanish hospitals and at international level. The resistome of ST175 was mainly determined by mutational events, with resistance traits common to all or nearly all of…