Usefulness of guideline recommendations for prognosis in patients with candidemia.

Last December the journal “Medical Mycology” published a multicenter study of adult patients with candidemia in 13 hospitals in Spain, lead by investigators of Bellvitge University Hospital. Candidemia is a common infection and is associated with high morbidity and mortality. Outcomes of patients with candidemia may be directly influenced by the general management, including diagnostic…

Understanding and modelling reservoirs, vehicles and transmission of ESBL-producing Enterobacteriaceae in the community and long-term care facilities: the MODERN project

MODERN is an international collaborative project investigating the reservoirs and transmission of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBL-E), funded by national institutions participating in the Joint Programme Initiative – Antimicrobial Resistance (JPI AMR) of the European Union with 1 million Euros. The project is coordinated by Hospital Universitario Virgen Macarena/University of Seville/Institute of Biomedicine of Seville,…

Scheduled monitoring of host’s immune responses is useful to prevent the development of opportunistic infections after kidney transplantation.

A recently published multicenter study led by Dr. Mario Fernández-Ruiz and Prof. José María Aguado, from the University Hospital “12 de Octubre” (Madrid), has confirmed the usefulness of a immune-based monitoring strategy to predict the risk of potentially severe opportunistic infections due to the reactivation of cytomegalovirus (CMV) in patients undergoing kidney transplantation. The study…

Antibiotic-induced genetic variation: how it arises and how it can be prevented.

In a recent publication (Annual Reviews of Microbiology), scientists belonging to REIPI (Centro Nacional de Biotecnología, Hospital Virgen del Rocío and Hospital Ramón y Cajal), in collaboration with the Université París Descartes-CNRS, have called the attention on the dangerous side effects of antibiotics because of their capacity to accelerate the rise of antibiotic resistant bacteria.…

Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy.

“The sharp increase in cases of MDR Acinetobacter baumannii infections in recent years prompted by WHO to list this pathogen as a critical pathogen. The development of new approaches that adjuvant the scarcity of clinically relevant antibiotics for treatment of infections by MDR A. baumannii is an urgent need. Researchers from the University Hospital Virgen…

Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli.

Journal of Antimicrobial Chemotherapy 2018 (In press)   This study was coordinated at University Hospital Virgen Macarena in collaboration with the Centro Nacional de Biotecnología. This work shows that suppression of the SOS response (through recA deleted) blocks the evolution towards clinical quinolone resistance across a range of E. coli phenotypes from highly susceptible to…

Analysis of intestinal colonization by ESBL-E. coli reveals the emergence in Europe of CTX-M-27 associated with clade C1-M27 of ST131 clone

– This finding represents an epidemiological change in extended-expectrum-beta-lactamases (ESBLs) distribution in Europe – This study results from the collaboration of the Preventive Medicine and Microbiology Departments at Hospital Universitario Ramón y Cajal (Madrid) with a European multicentre project (R-GNOSIS) funded by the EU and it has been recently awarded as best communication in the…

I Jornada sobre Bilógicos, Seguridad e Infección (BI-SEIF). Madrid, 19 de Septiembre de 2018

CARTA DE BIENVENIDA   Nos complace presentar las Primeras Jornadas sobre Biológicos Seguridad e Infección (BI-SEIF). Estas Jornadas nacen con el propósito de desarrollar las bases para el uso seguro de los nuevos fármacos biológicos dirigidos al tratamiento de cada vez más enfermedades en el campo de la Oncología, Hematología, Reumatología, Dermatología, Aparato Digestivo, Nefrología,…