Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli.

Journal of Antimicrobial Chemotherapy 2018 (In press)   This study was coordinated at University Hospital Virgen Macarena in collaboration with the Centro Nacional de Biotecnología. This work shows that suppression of the SOS response (through recA deleted) blocks the evolution towards clinical quinolone resistance across a range of E. coli phenotypes from highly susceptible to…