Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial. Lancet Haematol 2017

The optimal duration of empirical antibacterial therapy for febrile neutropenia without microbiological diagnosis in haematological patients is not well defined; the classical approach of continuing antimicrobial therapy until neutrophil recovery may prolong it unnecessarily. This study aimed to establish whether the discontinuation of antimicrobial therapy driven by a clinical approach regardless of neutrophil recovery would…