High Resolution Melting Assay to detect azole resistance in Aspergillus fumigatus

The global emergence of azole resistant Aspergillus fumigatus strains is a growing public health concern. Different patterns of azole resistance are linked to mutations in cyp51A. The Mycology Reference Laboratory of the National Centre for Microbiology has developed and validated a new screening sequencing-free molecular method based in a High Resolution Melting (HRM) assay to…

Empiric Therapy with Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae: Results from the INCREMENT Cohort.

This study, in advance access published in Clinical Infectious Diseases in August 2017, was coordinated at University Hospital Virgen Macarena with the collaboration of a large number of hospitals belonging to the REIPI/ESGBIS/INCREMENT group included in the REIPI network. The most relevant results, described below, can have a significant impact in the treatment and outcome…