Human neutrophils kill Acinetobacter

Using different advanced microscopy techniques, a group of researchers from the REIPI network demonstrated that human neutrophils easily phagocytose and kill Acinetobacter baumannii and A. pittii. After bacteria-cell contact, neutrophils rapidly and continuously engulf and kill bacteria during at least 4 hours of infection in vitro. Also, neutrophils release neutrophil extracellular traps (NETs) against Acinetobacter.…

Blocking cell-wall recycling to potentiate the activity of β-lactams and fosfomycin against Pseudomonas aeruginosa

REPI researchers from H. Son Espases and CNB-CSIC, in collaboration with Canadian and Australian researchers, have evaluated the interconnection between peptidoglycan (PG) recycling, fosfomycin susceptibility and synergy between fosfomycin and β-lactams in Pseudomonas aeruginosa. Mutants defective in AmpG, NagZ or all three AmpD amidases showed a marked increase in fosfomycin susceptibility. Moreover, fosfomycin MICs were…