Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial

How Long? the just Continuation of empirical antimicrobial therapy (EAT) for febrile neutropenia in patients with haematological malignancies until neutrophil recovery could prolong the therapy innecessarily. We did an investigator-driven, superiority, open-label, randomised, controlled phase 4 clinical trial in six hospitals in Spain. For the experimental group, EAT was withdrawn after 72 h or more…

High Resolution Melting Assay to detect azole resistance in Aspergillus fumigatus

The global emergence of azole resistant Aspergillus fumigatus strains is a growing public health concern. Different patterns of azole resistance are linked to mutations in cyp51A. The Mycology Reference Laboratory of the National Centre for Microbiology has developed and validated a new screening sequencing-free molecular method based in a High Resolution Melting (HRM) assay to…

Empiric Therapy with Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae: Results from the INCREMENT Cohort.

This study, in advance access published in Clinical Infectious Diseases in August 2017, was coordinated at University Hospital Virgen Macarena with the collaboration of a large number of hospitals belonging to the REIPI/ESGBIS/INCREMENT group included in the REIPI network. The most relevant results, described below, can have a significant impact in the treatment and outcome…

Decipher of lung microbiome from cystic fibrosis patients reveals the presence of predator bacteria

The presence of predatory bacteria in the respiratory microbiome in patients with cystic fibrosis opens new research projects for their treatment This discovery is the result of the collaboration of REIPI centers integrated in the Spanish Group for the Study of Colonization/Bronchopulmonary Infection in Cystic Fibrosis involving 24 Clinical Units of Cystic Fibrosis in Spain…

Cellular Response to Ciprofloxacin in Low-Level Quinolone-Resistant Escherichia coli

Machuca J, Recacha E, Briales A, Díaz-de-Alba P, Blazquez J, Pascual Á, Rodríguez-Martínez JM. Unidad Intercentros de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena y Virgen del Rocío, Seville, Spain; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Sevilla, Spain; Red Española de Investigación…

Quinolone resistance reversion by targeting the SOS response

E. Recacha, J. Machuca, P. Díaz de Alba, M. Ramos-Güelfo, F. Docobo-Pérez, J. Rodriguez-Beltrán, J. Blázquez, A. Pascual, J.M. Rodríguez-Martínez. Unidad de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Seville, Spain; Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III,…